TP53 and melanoma: Survivin is normally repressed by P53 in human melanocytes [41] as shown in the current study (Table 4), but was shown to be down-regulated in melanoma cell lines with null/mutant P53 when compared to those with wild-type P53 and was not altered by inhibition of P53 expression in melanoma, further suggesting aberrant transcriptional regulation of this target gene by P53 in melanoma.