TP53 and melanoma: To determine whether altered regulation of P53 target genes could be recapitulated in vitro, the mRNA expression of the 290 probes (Additional file 1, Table S1) were examined in six melanoma cell lines, including four with wild-type P53 (IgR3, Mel-RM, MM200, Me1007), one with no P53 expression (Me4405) and one with mutant P53 (Sk-Mel-28, G454A) [16].