MMP1 and neoplasm: Most of the differentially expressed genes have been previously shown to be involved in tumor invasion and metastasis, such as matrix metallopeptidase 1 [21], LOXL2 [22], cadherin 16 [23], lectin galactoside-binding soluble protein1 [24], thymidine phosphorylase [25] and LY6/PLAUR domain containing 3 [26].