For instance, ritximab (Mabthera) has been used against the CD20 antigen on B-cell non-Hodgkin’s lymphomas (NHLs), and trastuzumab (herceptin) has been directed at the human epidermal growth factor receptor 2 (HER-2) in breast cancer. The gene discussed is MS4A1; the disease is B-cell non-Hodgkin lymphoma.