Moreover, in rats with renal cysticdisease caused by a mutation in MKS3, the laminar organizationof the OE is perturbed and there is a reduced expression of components of theodor transduction cascade (Golf, AC3) and α-acetylated tubulin.Furthermore, we show with electron microscopy that cilia inMKS3 mutant animals do not manifest the proper microtubulearchitecture. The gene discussed is ADCY3; the disease is cystic kidney disease.