The tumorigenic ability of eIF5-A2 has been demonstrated by several in vitro evidences: eIF-5A2 stably transfected LO2 cells (immortalized human liver cell line) displayed increased colony formation in soft agar and xenograph formation in nude mice; reduction of eIF-5A2 in ovarian cancer cell line UACC-1598 inhibits cell growth; and the oncogenic ability of eIF5-A2 can be blocked by eIF-5A2 silencing [7-9]. The gene discussed is EIF5A2; the disease is ovarian cancer.