LEP and Schnyder corneal dystrophy: Given the fact that HbSS patients are inadequate in cellular immunity [7-10], hypercatabolic in metabolism [27], prone to anorexia and growth deficit, elicits higher resting energy expenditure (28) and experience chronic haemolytic and inflammatory episodes even in the steady state relative to non-SCD humans [29], there is a need to understand the possible role of leptin in the pathophysiology of HbSS.