On the effect of haemolysis, inflammation and sickling on leptinemia among the SCA patients, we found non-significant (P > 0.05) association between leptin and haemolytic parameters (PCV, MCHC, MCH, RBC) measured; negative but significant correlation between leptin and ESR (r = -0.55 to -0.79; P <0.01) and between leptin and platelet count (r = -0.39; P = 0.03) only in stable patients. The gene discussed is LEP; the disease is autosomal dominant cerebellar ataxia.