In this paper, we fully use the advantages of FMNPs and BRCAA1 antigen, prepared monoclonal antibody against BRCAA1 protein, and prepared BRCAA1 monoclonal antibody-conjugated fluorescent magnetic nanoprobes (BRCAA1-FMNPs), employed nude mice model loaded with gastric cancer of 5 mm in diameter and IVIS imaging system and Magnetic Resonance Imaging, investigated the feasibility of as-prepared nanoprobes for non-invasive in vivo targeted dual modal imaging of gastric cancer. Here, ARID4B is linked to gastric cancer.