Here we show that in keratinocytes GATA3 is strongly induced by IL-4.Psoriasis is currently viewed as a predominantly Th1/Th17 disease, where the Th1cytokines (IFN-γ) and Th17 cytokines (IL-17, IL-22) together with IL-23 suppressthe production of IL-4 in T lymphocytes. The gene discussed is IFNG; the disease is psoriasis.