CCN2 and gingival overgrowth: CCN2 expression correlates wellwith the onset of tissue repair and fibrotic conditions, including those affectingthe oral cavity such as phenytoin-induced gingival overgrowth or hereditary gingivalfibromatosis [10]–[15], and appears to contribute to collagen deposition inthese processes; for example, mice deficient in CCN2 expression in dermalfibroblasts are resistant to bleomycin-induced skin fibrosis [16].