Stromal reaction to invasive breast carcinoma was associated with increased expression of genes encoding ECM components, proteolytic enzymes and adhesion receptors, including COL11A1, COL10A1, COMP, MMP11, FN1 and MFAP2, consistent with the abundant stromal remodeling observed by histology. The gene discussed is MFAP2; the disease is invasive breast carcinoma.