The median tumor weight in the control group was 714 mg (interquartile range 470-1278); in the topotecan group it was 419 mg (325-540, p = 0.06); in the IL-18 group it was 437.5 mg (240-650, p = 0.066); and in the combination group it was 267 mg (160-360, p = 0.012). Here, IL18 is linked to neoplasm.