In addition to the turnover of cyclin E [10] and c-Jun, Fbw7 is also involved in the degradation of c-Myc [18, 19], and the Notch-1 protein [20] (Figure 1), all of which have been reported to possess oncogenic functions and are frequently found to be overexpressed in various human cancers, including leukemia. The gene discussed is FBXW7; the disease is leukemia.