While the underlying mechanisms linking non-HDL-C and risk of mortality from IHD and stroke need to elucidated, non-HDL-C concentration could be a marker of atherogenic and pathophysiologic effects of multiple apolipoprotein B-containing lipoproteins and triglyceride-rich lipoproteins including LDL, VLDL, IDL, and lipoprotein (a). This evidence concerns the gene APOB and Stroke.