In light of recent findings which suggest that metformin may act via an insulin dependent mechanism in the human ovary, this treatment may confer a significant effect on oocyte development and ovulatory performance in the dbdb mouse and a subset of similarly hyperleptinemic and hyperinsulinemic women with PCOS [55], Additionally, the larger follicular endowment of db/db mice, compared to other genotypes, may also contribute an unknown influence on oocyte maturation and development during superovulation. Here, INS is linked to polycystic ovary syndrome.