INS and polycystic ovary syndrome: In line with prior observations of dysfunctional steroidogenesis and folliculogenesis in PCOS [49], correction of this metabolic derangement with the insulin sensitizer, metformin, may have established a more favorable intrafollicular insulin environment and may have optimized ovulatory performance, resulting in an improvement in the production of mature oocytes during superovulation in the db/db strain.