NF1 and aneurysm: In a study on 143 pediatric patients with MMD in North America, Scott et al.12 observed that nearly all the patients had clinical symptoms of aneurysm or transitory ischemic attacks, and similar results have been reported in European studies.13 In a cohort study on 316 children with NF-1, Rosser et al.3 observed cerebral vasculopathy in eight of them (2.5%), with only two cases (0.6%) also presenting MMS.