In this study,we examined four different measures of RELN expression: totalexpression, allelic expression and two alternative RELN isoforms.In contrast to some of the previous studies, we did not find a significant reductionin the total expression of RELN in postmortem brain samples frompatients with schizophrenia or bipolar disorder, even though the sample size wasrelatively large. This evidence concerns the gene RELN and bipolar disorder.