The allelic expression imbalance in schizophrenia andthe lack of association between RELN expression and geneticvariations, suggests that cis-acting factors, such as epigeneticmutations or genetic imprinting defects, are associated with RELNdysfunction in schizophrenia and possibly other neuropsychiatric disorders.Additional studies are needed to test the generality of our findings. Here, RELN is linked to schizophrenia.