ADIPOQ and type 2 diabetes mellitus: Two SNPs located on exon 2 (+45T>G, a synonymous mutation, Gly15Gly) and intron 2 (+276G>T) of the ADIPOQ gene were reported to be associated with both plasma adiponectin concentrations and type 2 diabetes (T2D) in Japanese, German, and Italian populations [7-9].