This paper describes experiments conducted to investigate and compare the effects of IL-6 and TNF-α blockade on the development of TB infection in mice by examining various indicators of disease in TB-challenged mice treated with antibodies to IL-6R and TNF-α and also in TB-challenged IL-6 knockout (KO), TNF-α receptor 1 (TNFR1) KO, and TNFR1/IL-6 double-KO (DKO) mice. Here, TNF is linked to tuberculosis.