GNRH1 and precocious puberty: The diagnosis of gonadotropin-dependent precocious puberty is made by demonstrating apubertal luteinizing hormone (LH) at baseline (specifically LH/follicle stimulatinghormone (FSH) ratio > 0.2) [31] or in response togonadotropin-releasing hormone (GnRH) or GnRH analog (GnRHa) stimulation [32–40].