The minimal criteria required for the diagnosis of ABPA are (1) asthma or cystic fibrosis with deterioration of lung function, for example, wheezing, (2) immediate Aspergillus skin test reactivity, (3) total serum IgE ≥1000 IU/mL, (4) elevated Aspergillus specific IgE and IgG antibodies, and (5) chest radiographic infiltrates (Table 1). This evidence concerns the gene IGHE and asthma.