IGHE and cystic fibrosis: The most recent Cystic Fibrosis Foundation Consensus Conference proposed the following diagnostic criteria: (1) acute or subacute pulmonary deterioration not attributable to another etiology, (2) total serum IgE > 1000 IU/mL, (3) immediate cutaneous reactivity to Aspergillus or in vitro specific IgE antibodies to Aspergillus, and (4) one of the following: Aspergillus serum precipitins, elevated specific IgG anti-Aspergillus antibodies, or new or recent chest radiographic or chest CT abnormalities that have not cleared with antibiotics and chest physiotherapy (Table 2) [23].