This entry is assisted by a number of tethering proteins that are constitutively expressed in the sinusoid epithelium, such as vascular cell adhesion molecule 1 (VCAM-1), as well as decreased rates of blood flow within the sinusoids themselves, which allow prostate cancer cells to adhere and localize to these sites [14,15]. The gene discussed is VCAM1; the disease is Familial prostate cancer.