GSK3B and amyotrophic lateral sclerosis: Yang et al. reported that the expression of GSK-3β and phospho-beta-catenin, which reflects the activity of GSK-3β, was increased in ALS patients compared to that of controls and that GSK-3β immunoreactive neurons were mainly located in layer II and layer III of the frontal cortex and in layer II of the hippocampus [35].