It was recently reported that increased serum levels of CRP existed among Iranian women with raised waist circumference and elevated triglyceride.18 We have documented in the TARF study that low-grade systemic inflammation and oxidative stress were determinants of diabetes and CHD, independent of waist circumference, fasting glucose and HOMA in women though not in men.19 A 3-fold increment in multivariably adjusted CRP levels would predict the development of diabetes. The gene discussed is CRP; the disease is coronary artery disorder.