Although both Pyk2 and FAK were expressed in the glioblastoma cells and human brain MvEC, we found that FIP200 preferentially co-immunoprecipitated with Pyk2 in the absence of FIP200 downregulation in the unmanipulated U-87MG glioblastoma and brain MvEC cells propagated in complete media. The gene discussed is PTK2B; the disease is glioblastoma.