RB1CC1 and neoplasm: The U-87MG cell line was selected for these studies as it expressed intermediate levels of FIP200 as compared to the other cell lines tested (Figure S2A), immortalized human astrocytes (E6/E7 cells) were used as a model for the tumor-associated glial cells [28], and cultured human brain microvessel endothelial cells were used as a model for the endothelial cells in the tumor-associated vessels [29], [30].