In northern Pakistan, the genes most commonly mutated in LCA are RPGRIP1 (29% of families), AIPL1 (21% of families), and LCA5 (21% of families); whereas in Caucasian populations, mutations in RPGRIP1, AIPL1, and LCA5 account for only 4.2%, 5.3%, and 1.8% of LCA cases, respectively [2]. This evidence concerns the gene LCA5 and Leber congenital amaurosis.