CDKN2C and neoplasm: An important tumor suppressorgene located in this locus is RUNX3 which is often deleted orhypermethylated in various cancers showing epithelial, hematopoietic, and neuralphenotypes [24].Eighteen of twenty (90%) chordoma cases showed hemizygous loss of 1p36,suggesting the relevance of examining RUNX3 as well as otherpotential 1p36 tumor suppressor genes in chordomas in future studies (e.g.,CDH5, TP73, or CDKN2C).