An important tumor suppressorgene located in this locus is RUNX3 which is often deleted orhypermethylated in various cancers showing epithelial, hematopoietic, and neuralphenotypes [24].Eighteen of twenty (90%) chordoma cases showed hemizygous loss of 1p36,suggesting the relevance of examining RUNX3 as well as otherpotential 1p36 tumor suppressor genes in chordomas in future studies (e.g.,CDH5, TP73, or CDKN2C). This evidence concerns the gene CDH5 and cancer.