Simple logistic regression analysis demonstrated that plasma A-FABP, smoking, body mass index, diabetes mellitus, hypertension, dyslipidemia, renal dysfunction, hsCRP, and the use of ACEI/ARBs, CCBs, and statins were significant factors associated with the presence of CAD, Multiple logistic regression analysis including all significant factors in subjects aged < 65 years revealed that the increase in plasma A-FABP was independently associated with the presence of CAD (p = 0.001) along with smoking and diabetes mellitus. This evidence concerns the gene FABP4 and metabolic syndrome.