Our finding of an association between the PRNP G310C, which is a SNP located in the regulatory region of the gene, and an increased risk and earlier age at onset of sCJD, might suggest that the mutant PRNP 310C allele may increase the expression of PRNP. According to the stochastic protein conformational change theory, the risk of developing CJD may increase proportionally with the level of the PRNP product, the cellular prion protein (PrPC) available [20]. Here, PRNP is linked to Creutzfeldt Jacob disease.