Combination of PEP-1-SOD1 and PEP-1-CAT not only more effectively and completely remove O2- or H2O2, thus produce more oxygen to prevent oxygen deficiency, but also reduce myocardial apoptosis by blocking apoptotic factors such as CK, CK-MB, cTnT, LDH, MDA, which minimize the myocardial infarction, leading to an improved LV function. This evidence concerns the gene SOD1 and myocardial infarction.