Moreover, eryptosis is enhanced in several clinical conditions, such as iron deficiency [43], sickle-cell anaemia [79,80], beta-thalassaemia [22], glucose-6-phosphate dehydrogenase (G6PD)-deficiency [22], phosphate depletion [81], Haemolytic uremic syndrome [82], sepsis [83], malaria [45] and Wilson's disease [84]. Here, G6PD is linked to sickle cell disease.