Enhanced susceptibility to eryptosis and accelerated clearance of Plasmodium-infected erythrocytes may confer relative protection against a severe course of malaria in carriers of sickle-cell trait, beta-thalassaemia-trait, homozygous Hb-C and G6PD-deficiency [46-50], in iron deficiency [21], as well as during treatment with lead [20], chlorpromazine [51] and cyclosporine [52]. The gene discussed is GSTM1; the disease is malaria.