Previous study on both colorectal carcinomas and hepatoblastomas has suggested that up-regulation of NKD1 mRNA could be a marker of activation of the Wnt signaling pathway in those tumors; while this up-regulation seemed to correlate with β-catenin mutational status in colon cancer, it was generalized in hepatoblastomas. Here, NKD1 is linked to malignant colon neoplasm.