In addition, we ablated NKD1 by siRNA technology in lung cancer cell lines to investigate alterations in Dishevelled-1 and β-catenin protein levels, MMP-7 transcription and the invasive ability of NKD1-knockdown lung cancer cells, to provide insight into the role of NDK1 in the biological behavior of lung cancers. The gene discussed is NKD1; the disease is lung carcinoma.