Obesity is associated with "low-grade inflammation" [4-6], a term that is used to reflect increments in the systemic concentration of tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-1ra, and C-reactive protein (CRP) [7]. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.