Thus, one can conclude from the present results that the training protocol used (suitable and accepted for healthy animals to improve their innate immune response against pathogens) leads to a situation of stress and inflammation in MS animals, manifest in their raised circulating levels of NA, and that these could contribute (or vice versa) to increasing the concentration of IL-6 and CRP that will ultimately affect the regulation of glucose homoeostasis in these obese animals. Here, IL6 is linked to myeloid sarcoma.