Homozygous mutation in the ALX4 gene was found to be associated with frontofacionasal dystosis syndrome, characterized by total alopecia, a large skull defect, coronal craniosynostosis, hypertelorism, a severely depressed nasal bridge and ridge, a bifid nasal tip, hypogonadism, callosal body agenesis, and mental retardation [21]. Here, ALX4 is linked to hypogonadism.