Cetuximab alone (monotherapy) eradicated established xenograft A431 epidermoid carcinoma tumours and inhibited tumour growth of breast, renal, pancreatic, head and neck, prostate, ovarian, and non-small cell lung carcinomas (NSCLC; including NSCLC xenograft tumors that express clinically relevant kinase domain mutants) that expressed 9000 to greater than1.6 × 106 EGFR molecules/cell [24]. Here, EGFR is linked to non-small cell lung carcinoma.