We now report results of our investigation into the association of the rs8192678 PGC-1α polymorphism with risk for PD and age of onset of PD, either alone or in combination with the A10398G mtDNA polymorphism and exploratory analyses of the association of 14 other PGC-1α SNPs and the A10398G mtDNA polymorphism with PD. The gene discussed is PPARGC1A; the disease is Parkinson disease.