Variants of the rs8192678 PGC-1α polymorphism have previously been studied alongside polymorphisms in peroxisome proliferator-activated receptor delta (PPARD) and sirtuin 1 (SIRT1) in relation to Alzheimer's disease and were found not to be associated with AD in a Finnish case-control situation [50]. This evidence concerns the gene PPARGC1A and early-onset autosomal dominant Alzheimer disease.