A significant (p = 0.044) interaction was also found between the PGC-1α rs7695542 and ND3 A10398G SNPs in the PD-ALL-LATE cohort, with the combined CT and A genotypes conferring earlier age of onset, but this was not replicated across other PD subgroups. The gene discussed is PPARGC1A; the disease is acute lymphoblastic leukemia.