Furthermore, we have found that rs2837960 is associated with both RA and AD and that it, or one of its proxy SNPs, may modulate the expression of BACE2. As we learn more about the pathologic processes behind both RA and AD, including the contribution of BACE2 to each disease, a greater understanding of the factors underlying the inverse relationship between these two diseases may be obtained. This evidence concerns the gene BACE2 and rheumatoid arthritis.