When correlating the ATP concentrations with the NRF-1 and TFAM genotypes, HD patients carrying at least one rare NRF-1 rs7781972 allele showed significantly lower ATP concentrations (487.1 ± 179 ng, n = 8; 436.7 ± 135.1 ng, n = 4) than homozygous individuals carrying the frequent allele (600.6 ± 48.7 ng, n = 9, p = 0.03; Figure 2). This evidence concerns the gene NRF1 and Huntington disease.