When considering the highest IP-10 response to either ESAT-6 or CFP-10 selected peptides per single patient, the IP-10 secretion was significantly higher at the time of diagnosis (median: 5116 pg/ml; IQR: 2207-7063) than at therapy completion(T6) (median: 73 pg/ml; IQR: 0-5222) (p = 0.0060) (Figure 3A) Using the cut-off point of 350 pg/ml, previously found by ROC analysis [38] (Table 2), 16 out of 17 subjects (94.1%) scored positive for IP-10 at the time of TB diagnosis. The gene discussed is CXCL10; the disease is tuberculosis.