TP53 and neoplasm: In LNCaP cells miR-134 is very significantly up regulated by 1,25(OH)2D3 in the absence and presence of T. The role of miR-134 in prostate cancer has not been previously described, however the steady state level of miR-134 is modulated by members of the p53/p73/p63 family as part of a miRNA-tumor suppressor network [64].