Serum esRAGE in CAD group was lower, while hsCRP and MRP8/14 were significantly higher than non-CAD group (0.26 ± 0.18 ng/ml vs. 0.31 ± 0.16 ng/ml for esRAGE; 15.4 ± 15.9 mg/L vs. 6.7 ± 11.1 mg/L for hsCRP; 9.7 ± 3.6 ug/ml vs. 8.2 ± 3.0 ug/ml for MRP8/14, all P < 0.05). The gene discussed is S100A8; the disease is coronary artery disorder.