As shown in Figure 6, the percentages of immunopositive cells for COX2 or activated Akt were much higher in high-grade urothelial carcinomas, including CIS, with both minimal (pT1) and wide invasion (≧pT2) than in low-grade (G1 and G2) lesions with a noninvasive phenotype (pTa). The gene discussed is AKT1; the disease is in situ carcinoma.