Biomarkers of inflammation, such as TNF-α, interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1, CCL2), and C-reactive protein, are increased in obesity, associated with insulin resistance, and predict the development of type 2 diabetes [13]–[16]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.