Incubations with peptides corresponding towell-characterized HLA-B*0702-restricted immunodominant epitopes from HIV-1Gag classical ORF (SPRTLNAWV, TPQDLNTML, YPLASLRSLF) induced a significantIFNγ-release, demonstrating that in the course of natural infection thedonors mounted CTL responses to HIV-1 antigens. This evidence concerns the gene HLA-B and infection.