It is interesting to note that ARF-specificCD8+ T cells can performed multiple functions [33], [34] and control viral replicationin vitro, characteristics that correlate with slow diseaseprogression [57].In addition, CTLs targeting ARF-derived epitopes can be induced upon vaccination[58] and tumorinfiltrating CTLs specific for ARFPs have been also identified in various cancers,including melanoma and breast cancers [25]. The gene discussed is CDKN2A; the disease is melanoma.