Given that HCMV infection or ectopic expression of IE1 or IE2 leads to increased E2F activity [17], [31], [32], [33], we asked whether E2F1 or other RB-associated, activator E2Fs were responsible for the DDR following HCMV infection or IE cDNA transduction. The gene discussed is E2F1; the disease is cytomegalovirus infection.