Table 1 summarizes genes differentially induced more than two-fold by the combination therapy in both cell lines. The expression changes of some of the genes involved in cancer metastasis, cell cycle, DNA repair, DNA binding and cell proliferation, including Phosphatase of regenerating liver-3 (PRL-3, also named as PTP4A3), ORC1L, MND1, ZNF85 and LMO4 were confirmed by RQ-PCR at the mRNA level (Table S1 and Figure S1). This evidence concerns the gene ORC1 and cancer.