To identify cancer-restricted plasma proteins, we compared the plasma proteomes of mice with carageenan-induced subacute inflammation, collagen-induced arthritis, and FGF-induced angiogenesis to the plasma proteomes of mice with PyMT driven breast cancer and Pdx1-Cre KrasG12D Ink4a/Arf lox/lox pancreatic cancer. Here, CDKN2A is linked to cancer.