Development of pancreatic cancer in the Pdx1-Cre KrasG12D Ink4a/Arflox/lox model involves progression from pancreatic intraepithelial neoplasia (PanINs) to pancreatic ductal adenocarcinoma (PDAC), faithfully recapitulating the human disease [24]. Here, PDX1 is linked to pancreatic neoplasm.