WNT5A and neoplasm: On the other hand, oncogenic roles have been identified in prostate cancer, where Wnt5a promotes cell motility (Wang et al, 2010; Yamamoto et al, 2010), melanoma, where expression associates with tumour invasion (Weeraratna et al, 2002), and hepatocellular carcinoma, where expression is associated with poorly differentiated and invasive cell lines (Yuzugullu et al, 2009).