WNT5A and colorectal carcinoma: Indeed, it has been proposed that these discordant functions of Wnt5a may affect CRC prognosis in a time-dependent manner, whereby early Wnt5a expression exerts a favourable effect by inhibiting tumour growth through canonical Wnt suppression, whereby late expression of Wnt5a exerts a deleterious effect by promoting tumour invasion through non-canonical Wnt activation (Wang, 2009).