In addition to its effects on non-canonical Wnt activity, Wnt5a is also known to inhibit β-catenin accumulation in CRC cells (Ying et al, 2008; Yuzugullu et al, 2009), suggesting that MSI and/or CIMP-high tumours may also experience preferential activation of canonical Wnt activity. This evidence concerns the gene WNT5A and colorectal carcinoma.