WNT5A and colorectal carcinoma: In an effort to determine the frequency of this event between CRC subtypes and its potential prognostic role, we examined Wnt5a promoter methylation levels in two distinct MSI-stratified Canadian populations: Ontario, a heterogeneous population with a moderate incidence of CRC, and Newfoundland, a founder population with a high incidence of CRC, particularly within families (Woods et al, 2005).