XRCC1 and cancer: One study found >10% of 28 GEJ cancers (including 3 cell lines and 2 xenografts) had gene amplification at a neighboring site (19q13.1) [31]; however, the density of CGH coverage is not clearly reported [32] so it is unknown whether amplification occurred at XRCC1. Together, these AI data, which require further evaluation and confirmation, provides biologic plausibility that assessing germline DNA is appropriate when attempting to predict response to RCT in EAC tumors.