Periodontitis caused by P gingivalis oral inoculation enhanced (p < 0.05) the maximal response to phenylephrine in all groups when compared to the respective control group in both C57 (Pg; 92 ± 6 versus Ct: 79 ± 3 mmHg) and ApoE (Pg: 119 ± 7 versus Ct: 98 ± 5 mmHg) groups (Figure 4B and 4D). The gene discussed is APOE; the disease is periodontitis.