Since intratumoral expression of MIF was correlated with serum IL-6 in patients with non-small cell lung cancer [48] and IL-6 was shown to be one of the potential MIF-regulated genes in DU145 cells [32], we speculate that NPRA signaling may regulate IL-6 in PCa cells via MIF. The gene discussed is NPR1; the disease is posterior cortical atrophy.